"*" indicates equal contribution
Italics indicate mentored lab member
Preprints
61.
Yang X,
Xu X, Chen Y, Wei J, Huang W, Wu S*,
Champer J*, Wang J*.
Assessment of drive efficiency and resistance allele formation of a homing gene drive in the mosquito Aedes aegypti.
bioRxiv, September 2024.
60.
Han Y,
Champer J.
A comparative assessment of self-limiting genetic control strategies for population suppression.
bioRxiv, September 2024.
59.
Zhang X,
Sun W, Kim IK, Messer PW,
Champer J.
Population dynamics in spatial suppression gene drive models and the effect of resistance, density dependence, and life history.
bioRxiv, August 2024.
58.
Xu X,
Chen J, Wang Y,
Liu Y, Zhang Y,
Yang J,
Yang X, He Z,
Champer J.
Gene drive-based population suppression in the malaria vector Anopheles stephensi.
bioRxiv, May 2024.
Journal Publications
57.
Faber N*,
Xu X*,
Chen J,
Hou S,
Du J, Pannebakker BA, Zwaan BJ, van den Heuvel J,
Champer J.
Improving the suppressive power of homing gene drive by co-targeting a distant-site female fertility gene.
Nature Communications, 2024.
56. Champer SE, Chae B, Haller BC,
Champer J, Messer PW.
Resource-explicit interactions in spatial population models.
Methods in Ecology and Evolution, 2024.
55. Wang GH, Hoffman A,
Champer J.
Gene drive and symbiont technologies for control of mosquito-borne diseases.
Annual Review of Entomology, 2024.
54.
Feng R,
Champer J.
Deployment of tethered gene drive for confined suppression in continuous space requires avoiding drive wave interference.
Molecular Ecology, 2024.
53.
Chen W,
Guo J,
Liu Y,
Champer J.
Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila.
Nature Communications, 2024.
52.
Zhu J*,
Chen J*,
Liu Y*,
Xu X,
Champer J.
Population suppression with dominant female-lethal alleles is boosted by homing gene drive.
BMC Biology, 2024.
51.
Champer J, Schlenoff D.
Battles between ants (Hymenoptera: Formicidae): a review.
Journal of Insect Science, 2024.
50.
Zhang S,
Champer J.
Performance characteristics allow for confinement of a CRISPR toxin-antidote gene drive for population suppression in a reaction-diffusion model.
Proceedings: Biological Sciences, 2024.
49. Liu Y, Jiao B,
Champer J, Qian W.
Overriding Mendelian inheritance in Arabidopsis with a CRISPR toxin-antidote gene drive that impairs pollen germination.
Nature Plants, 2024.
48.
Du J,
Chen W,
Jia X,
Xu X,
Yang E,
Zhou R,
Zhang Y,
Metzloff M, Messer PW,
Champer J.
Germline Cas9 promoters with improved performance for homing gene drive.
Nature Communications, 2024.
47.
Hou S*,
Chen J*,
Feng R,
Xu X, Liang N,
Champer J.
A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.
Journal of Genetics and Genomics, 2024.
46. Ma S*, Ni X*, Chen S, Qiao X,
Xu X,
Chen W,
Champer J, Huang J.
A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii.
PLoS Genetics, 2024.
45. Yang J,
Xu X, Wu J,
Champer J, Xie M.
Involvement of miR-8510a-3p in response to Cry1Ac protoxin by regulating PxABCG3 in Plutella xylostella.
International Journal of Biological Macromolecules, 2024.
44. Clark AC, Alexander A, Edison R, Esvelt K, Kamau S, Dutoit L,
Champer J, Champer S, Messer PW, Gemmell N.
A framework for identifying fertility gene targets for mammalian pest control.
Molecular Ecology Resources, 2023.
43.
Pan M,
Champer J.
Making waves: Comparative analysis of gene drive spread characteristics in a continuous space model.
Molecular Ecology, 2023.
42.
Liu Y,
Teo W,
Yang H,
Champer J.
Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models.
Ecology Letters, 2023.
41.
Zhu Y,
Champer J.
Simulations reveal high efficiency and confinement of a population suppression CRISPR toxin-antidote gene drive.
ACS Synthetic Biology, 2023.
40.
Chen J,
Xu X,
Champer J.
Assessment of distant-site rescue elements for CRISPR toxin-antidote gene drives.
Front Bioeng Biotechnol, 2023.
39.
Li J,
Champer J.
Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: a modeling study.
PLoS Genetics, 2023.
38.
Champer SE*,
Kim IK*, Clark AG, Messer PW,
Champer J.
Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure.
eLife, 2022.
37.
Langmüller AM*,
Champer J*,
Lapinska S,
Xie L,
Metzloff M,
Champer SE,
Liu J,
Xu Y,
Du J, Clark AG, Messer PW.
Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations.
eLife, 2022.
36.
Metzloff M,
Yang E, Dhole S, Clark AG, Messer PW,
Champer J.
Experimental demonstration of tethered gene drive systems for confined population modification or suppression.
BMC Biology, 2022.
35.
Liu Y,
Champer J.
Modelling homing suppression gene drive in haplodiploid organisms.
Proceedings: Biological Sciences, 2022.
34.
Yang E,
Metzloff M,
Langmüller AM,
Xu X, Clark AG, Messer PW,
Champer J.
A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles.
G3: Genes, Genomes, Genetics, 2022.
33. Wang GH,
Du J,
Chu CY, Madhav M, Hughes GL,
Champer J.
Symbionts and gene drive: two strategies to combat vector-borne disease.
Trends in Genetics, 2022.
32.
Champer SE, Oakes N, Sharma R, García-Díaz P,
Champer J, Messer PW.
Modeling CRISPR gene drives for suppression of invasive rodents.
PLoS Comput Biol, 17(12), e1009660, 2021.
31. Ferreira-Martins D*,
Champer J*, McCauley DW, Zhang Z, Docker MF.
Genetic control of invasive sea lamprey in the Great Lakes.
J Great Lakes Res, 47(S1), S764-S775, 2021.
30.
Champer J*,
Kim IK*,
Champer SE, Clark AG, Messer PW.
Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles.
Mol Ecol, 30(4), 1086-1101, 2021.
29. Long KC, Alphey L, Annas GJ, Bloss CS, Campbell KJ,
Champer J,
et al.
Core commitments for field trials of gene drive organisms.
Science, 370(6523), 1417-1419, 2020.
28.
Champer J*,
Champer SE*,
Kim IK, Clark AG, Messer PW.
Design and analysis of CRISPR-based underdominance toxin-antidote gene drives.
Evol Appl, 14(4), 1052-1069, 2020.
27.
Champer J*,
Yang E*,
Lee E,
Liu J, Clark AG, Messer PW.
A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population.
Proc Natl Acad Sci U S, 117(39), 24377-24383, 2020.
26.
Champer J,
Kim IK,
Champer SE, Clark AG, Messer PW.
Performance analysis of novel toxin-antidote CRISPR gene drive systems.
BMC Biol, 8(1), 27, 2020.
25.
Champer J,
Zhao J,
Champer SE,
Liu J, Messer PW.
Population dynamics of underdominance gene drive systems in continuous space.
ACS Synth Biol, 9(4), 779-792, 2020.
24.
Champer SE,
Liu C,
Oh SY,
Wen Z, Clark AG, Messer PW,
Champer J.
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs.
Sci Adv, 6(10), eaaz0525, 2020.
23.
Champer J,
Lee E,
Yang E,
Liu C, Clark AG, Messer PW.
A toxin-antidote CRISPR gene drive system for regional population modification.
Nat Commu, 11(1), 1082, 2020.
22.
Champer J*,
Wen Z*,
Luthra A,
Reeves R,
Chung J,
Liu C,
Lee YL,
Liu J,
Yang E, Messer PW, Clark AG.
CRISPR gene drive efficiency and resistance rate is highly heritable with no common genetic loci of large effect.
Genetics, 212(1), 334-341, 2019.
21.
Champer J,
Chung J,
Lee YL,
Liu C,
Yang E,
Wen Z, Clark AG, Messer PW.
Molecular safeguarding of CRISPR gene drive experiments.
Elife, 8, e41439, 2019.
20.
Liu J*,
Champer J*,
Langmüller AM,
Liu C,
Chung J,
Reeves R,
Lee YL,
Luthra L, Clark AG, Messer PW.
Maximum likelihood estimation of fitness components in experimental evolution.
Genetics, 211(3), 1005-1017, 2019.
19.
Yu Y, Dunway S,
Champer J, Kim J, Alikhan A.
Changing our microbiome: Probiotics in dermatology.
Br J Dermatol, 2019.
18.
Champer J*,
Liu J*,
Oh SY,
Reeves R,
Luthra L,
Oakes N, Clark AG, Messer PW.
Reducing resistance allele formation in CRISPR gene drive.
Proc Natl Acad Sci U S A, 115(21), 5522-5527, 2018.
17.
Champer M,
Wong AM,
Champer J, Brito IL, Messer PW, Hou JY, Wright JD.
The role of the vaginal microbiome in gynaecological cancer.
BJOG, 125(3), 309-315, 2018.
16.
Champer J,
Reeves R,
Oh SY,
Liu C,
Liu J, Clark AG, Messer PW.
Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations.
PLoS Genetics, 13(7), e1006796, 2017.
15.
Champer J, Buchman A, Akbari OS.
Cheating evolution: Engineering gene drives to manipulate the fate of wild populations.
Nat Rev Genet, 17, 146-159, 2016.
14.
Champer J, Ito JI, Clemons KV, Stevens DA, Kalkum M.
Proteomic analysis of pathogenic fungi reveals highly expressed conserved cell wall proteins.
J. Fungi, 2(1), 6, 2016.
13.
Yu Y*,
Champer J*, Agak GW, Kao S, Modlin RL, Kim J.
Different
Propionibacterium acnes phylotypes induce distinct immune responses and express unique surface and secreted proteomes.
J Invest Dermatol, 136(11), 2221-2228, 2016.
12.
Yu Y,
Champer J, Kim J.
Analysis of the surface, secreted, and intracellular proteome of
Propionibacterium acnes.
EuPA Open Proteom, 9, 1-7, 2015.
11.
Yu Y,
Champer J, Beynet DP, Kim J, Friedman AJ.
The role of the cutaneous microbiome in skin cancer: Lessons learned from the gut.
J Drugs Dermatol, 14(5), 461-465, 2015.
10.
Yu Y,
Champer J, Garbán H, Kim J.
Typing of
Propionibacterium acnes: A review of methods and comparative analysis.
Br J Dermatol, 172(5), 1204-1209, 2015.
9. Schmidt NW, Agak GW, Deshayes S,
Yu Y, Blacker A,
Champer J, Xian W, Kasko AM, Kim J, Wong GC.
PenTobra: An aminoglycoside with robust antimicrobial & membrane activity against
Propionibacterium acnes.
J Invest Dermatol, 135(6), 1581-1589, 2015.
8.
Taylor EJM,
Yu Y,
Champer J, Kim J.
Resveratrol demonstrates antimicrobial effects against
Propionibacterium acnes.
Dermatol Ther, 4, 249-257, 2014.
7. Chow A, Zhou W, Liu L, Fong MY,
Champer J, Van Haute D, Chin AR, Ren X, Gugiu BG, Meng Z, Huang W, Ngo V, Kortylewski M, Wang SE.
Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB.
Sci Rep 4, 5750, 2014.
6. Lehrnbecher T, Kalkum M,
Champer J, Tramsen L, Schmidt S, Klingebiel T.
Immunotherapy in invasive fungal infection-focus on invasive aspergillosis.
Curr Pharm Des, 19(20), 3689-3712, 2013.
5.
Champer J,
Patel J,
Fernando N,
Salehi E,
Wong V, Kim J.
Chitosan against cutaneous pathogens.
AMB Express, 3(1), 37, 2013.
4. Friedman AJ, Phan J, Schairer DO,
Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL, Kim J.
Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens.
J Invest Dermatol, 133(5), 1231-1239, 2013.
3.
Champer J, Diaz-Arevalo D,
Champer M, Hong TB,
Wong M,
Shannahoff M, Ito JI, Clemons KV, Stevens DA, Kalkum M.
Protein targets for broad-spectrum mycosis vaccines: quantitative proteomic analysis of
Aspergillus and
Coccidioides and comparisons with other fungal pathogens.
Ann N Y Acad Sci, 1273, 44-51, 2012.
2. Chandra M, Zang S, Li H, Zimmerman L,
Champer J, Chow A, Zhou W, Tsuyada A, Yu Y, Gao H, Ren X, Lin RJ, Wang SE.
Nuclear translocation of type I TGF-β receptor confers a novel function in RNA splicing.
Mol Cell Biol, 32(12), 2183-2195, 2012.
1. Bungau C, Camanzi B,
Champer J, Chen Y, Cline DB, Luscher R, Lewin JD, Smith PF, Smith NJT, Wang H.
Monte Carlo studies of combined shielding and veto techniques for neutron background reduction in underground dark matter experiments based on liquid noble gas targets.
Astroparticle Physics, 23, 97-115, 2005.