News

December 2022
New paper on bioRxiv: "Performance characteristics allow for confinement of a CRISPR toxin-antidote gene drive designed for population suppression in a reaction-diffusion model"
The Champer Lab welcomes undergraduate researcher Jialing Fang.
The Champer Lab welcomes rotating graduate student Wenqing Tian.

November 2022
The Champer Lab welcomes rotating graduate students Xuqing Feng and Weiwen Yang.
New paper on bioRxiv: "Making waves: Comparative analysis of gene drive spread characteristics in a continuous space model"
New paper on bioRxiv: "Simulations reveal high efficiency and confinement of a population suppression CRISPR toxin-antidote gene drive"

October 2022
The Champer Lab welcomes rotating graduate students Biao Zhang and Cao Yu.
Paper published in eLife (last postdoc paper!): "Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure".

September 2022
Paper published in eLife: "Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations".
The Champer Lab welcomes high school researcher Ruizhi (Rachel) Zhou.
The Champer Lab welcomes undergraduate researchers Zexuan Lu and Jinyue Zhu.
The Champer Lab welcomes rotating graduate students Ruobing Feng and Yinke Wu.

August 2022
New paper on bioRxiv: "Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: a modeling study"

June 2022
The Champer Lab welcomes undergraduate researchers Weitang Sun and Yuqi Zhang.
Congratulations to Shijie Zhang, WeiJian Teo, Haochen Yang, and Weizhe Chen for completing their undergraduate thesis work and successfully graduating!

May 2022
Paper published in BMC Biology: "Experimental demonstration of tethered gene drive systems for confined population modification or suppression".
New paper on bioRxiv: "Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models"

April 2022
Paper published in Proceedings B (first paper of the new lab!): "Modelling homing suppression gene drive in haplodiploid organisms". Congratulations, Yiran!
Paper published in G3: "A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles"

March 2022
New paper on bioRxiv: "Finding the strongest gene drive: Simulations reveal unexpected performance differences between Anopheles homing suppression drive candidates" (updated version published in October 2022)
The Champer Lab welcomes undergraduate researcher Mingzuyu Pan.
Review published in Trends in Genetics: "Symbionts and gene drive: two strategies to combat vector-borne disease"

February 2022
The Champer Lab welcomes undergraduate researcher Xiaozhen Yang.

December 2021
Paper published in PLOS Computational Biology: "Modeling CRISPR gene drives for suppression of invasive rodents"
The Champer Lab welcomes undergraduate researcher Weizhe Chen.
The Champer Lab welcomes volunteer researcher Jingheng Chen.

November 2021
The Champer Lab welcomes volunteer researcher Ziqian Xu.
Review article published in Journal of Great Lakes Research"Genetic control of invasive sea lamprey in the Great Lakes"

October 2021
The Champer Lab welcomes undergraduate researchers Jiahe (Carol) Li and Xinyue Zhang.
Talk at the Chinese Entomological Society conference.
New paper on bioRxiv: "Modeling homing suppression gene drive in haplodiploid organisms" (updated version published in April 2022)

September 2021
The Champer Lab welcomes rotating graduate student Siyang Zhou.

August 2021
Seminar at the Chinese Academy of Sciences Institute of Zoology. Thanks to hosts Zhen Zou and Guan-Hong Wang.
The Champer Lab welcomes undergraduate researchers Shijie Zhang and WeiJian Teo.
The Champer Lab welcomes volunteer reseacher Weiwei Chen.
The Champer Lab welcomes lab manager Li (Lily) Yang.

July 2021
The Champer Lab welcomes postdoc researcher Xuejiao Xu.
The Champer Lab welcomes research technician Xihua Jia.

June 2021
Talk at the Interdisciplinary Workshop on Synthetic Gene Drives. "Gene drive for population modification or suppression”
The Champer Lab welcomes undergraduate researcher Yutong Zhu.

May 2021
New paper on bioRxiv: "Experimental demonstration of tethered gene drive systems for confined population modification or suppression" (updated version published in May 2022)
The Champer Lab welcomes research technician Yiran Liu.
New paper on bioRxiv: "A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles" (updated version published in April 2022)
Jackson has arrived at Peking University. Special thanks to new lab members Jie Du (postdoc), Chenyi Chu (researcher), and Haonan Yang (graduate student) for helping to set things up.
New paper on bioRxiv: "Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations" (updated version published in September 2022)
Participated in the Target Malaria workshop "Plausible Pathways to Potential Harm"

----Start of the Champer Lab at Peking University on 21 May----

February 2021
Talk at the Canadian Conference for Fisheries Research annual meeting. "Population control of invasive fish using gene drive”

January 2021
Paper published in Molecular Ecology"Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type alleles"

December 2020
The Champer Lab welcomes Jie Du, a newly recruited postdoc who will join the lab when it opens in early 2021.
​ Paper published in Evolutionary Applications"Design and analysis of CRISPR‐based underdominance toxin‐antidote gene drives ​"

November 2020
New paper on bioRxiv: "Modeling CRISPR gene drives for suppression of invasive rodents" (updated version published in December 2021)
Jackson has accepted a faculty position at the School of Life Sciences at Peking University and the Peking-Tsinghua Center for Life Sciences.

September 2020
Paper published in PNAS"A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population"

March 2020
Paper published in BMC Biology: "Performance analysis of novel toxin-antidote CRISPR gene drive systems"
Press: Cornell researchers find safer approach to gene drives
Press: Improved CRISPR gene drive solves problems of old tech
Press: TARE May Be the Future of Genome Editing, Improving on CRISPR Gene Drive
Paper published in ACS Synthetic Biology: "Population dynamics of underdominance gene drive systems in continuous space"
An NIH/NIAID K22 grant has been funded for Jackson Champer, which will support his future laboratory.
Paper published in Science Advances"Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs"

February 2020
Paper published in Nature Communications"A toxin-antidote CRISPR gene drive system for regional population modification"

December 2019
New paper on bioRxiv: "Design and analysis of CRISPR-based underdominance toxin-antidote gene drives" (updated version published in December 2020)

November 2019
Congratulations to Emily Yang for presenting a talk at the Entomology Society of America
 Conference! "A CRISPR homing gene drive targeting a haplolethal gene with rescue averts resistance"
Talk at the Entomology Society of America Conference. "Experimental and computational tests of CRISPR toxin-antidote gene drive strategies

October 2019​
Congratulations to Emily Yang for receiving a Cornell research grant for our experiments!

September 2019​
New paper on bioRxiv "Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles" (updated version published in January 2021)

July 2019​
Talk at the EMBO Vector conference. "Experimental and computational tests of new gene drive strategies​"
Talk at the Sea Lamprey International Symposium. “CRISPR gene drive as a tool for control of the sea lamprey”

June 2019
Seminar at the University of Melbourne. “Experimental and computational tests of novel CRISPR gene drive strategies”
Participated in the ILSI workshop "
Gene Drive Modeling Conference"
New paper on bioRxiv: "
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs" (updated version published in March 2020)
Talk at the Evolution 2019 joint conference. "Computational and experimental tests of new CRISPR gene drive strategies​"
Congratulations to Isabel Kim for being selected as a member of the 
Hunter R. Rawlings III Cornell Presidential Research Scholars Program!

May 2019​
Congratulations to Emily Yang for winning the Cornell Molecular and Cellular Biology poster competition! "A CRISPR gene drive eliminates resistance with haplolethal target and rescue allele"
New paper on bioRxiv: "Performance analysis of novel toxin-antidote CRISPR gene drive systems" (updated version published in March 2020)
New paper on bioRxiv: "A toxin-antidote CRISPR gene drive system for regional population modification" (updated version published in February 2020)
Participated in the FNIH workshop "Data Needs and Assay Design for Decision Making on Gene Drive-Modified Mosquitoes"
New paper on bioRxiv: "Resistance is futile: A CRISPR homing gene drive targeting a haplolethal gene" (updated version published in September 2020)
Congratulations to Isabel Kim for presenting a poster at the Great Lakes Evolutionary Genomics Symposium! "Suppression gene drives in continuous space can demonstrate unstable long-term population dynamics"

April 2019
Congratulations to Jingxian Liu and Zhaoxin Wen for completing their honors thesis requirements! These theses were based on their Genetics papers published in January and March of this year.
Press: 
eLife Podcast

March 2019
Paper published in Genetics: "CRISPR gene drive efficiency and resistance rate is highly heritable with no common genetic loci of large effect"
Press: Keeping gene drives in check

January 2019
Paper published in eLife: "Molecular safeguarding of CRISPR gene drive experiments"
Paper published in Genetics: "Maximum likelihood estimation of fitness components in experimental evolution"
Press: Scientists demonstrate effective strategies for safeguarding CRISPR gene-drive experiments

November 2018
Talk at the Entomological Society of America Joint Annual Meeting. "Can CRISPR gene drive succeed in natural populations?​"

October 2018
New paper on bioRxiv: "Population dynamics of underdominance gene drive systems in continuous space" (updated version published in March 2020)
New paper on bioRxiv: "Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene drive" (updated version published in March 2019)

September 2018
New paper on bioRxiv: "Molecular safeguarding of CRISPR gene drive experiments" (updated version published in January 2019)
Congratulations to Jingxian Liu for receiving a Cornell research grant for our experiments!

August 2018
Congratulations to Zhaoxin Wen for presenting a talk at the Cornell undergraduate research symposium! "A genome-wide association study to identify genetic factors affecting CRISPR gene drives​"

June 2018
New paper on bioRxiv: "Maximum likelihood estimation of fitness components in experimental evolution" (updated version published in January 2019)

May 2018
Paper published in PNAS: "Reducing resistance allele formation in CRISPR gene drive"
Poster presentation at the Genetics Society of America Drosophila PEQG Conference. "A genome-wide association study to identify genetic factors affecting resistance allele formation in CRISPR gene drives”
Press: Researchers Hit Roadblocks with Gene Drives

April 2018
Grant awarded: NIH F32 "Dynamics of gene drives in natural populations"
Talk at the Genetics Society of America Drosophila Research Conference. "A genome-wide association study to identify genetic factors affecting resistance allele formation in CRISPR gene drives”
Congratulations to Jingxian Liu for receiving the 
Victoria Finnerty Undergraduate Travel Award and presenting a talk at the Genetics Society of America Drosophila Research Conference! "Maximum likelihood estimation of sex-dependent fitness costs of a yellow mutant allele in Drosophila melanogaster"

November 2017
Congratulations to Chen Liu and Jingxian Liu for presenting a poster at the Ivy League Undergraduate Research Symposium! "Characterization and Improvement of CRISPR Homing Gene Drives"

August 2017
Grant awarded: NIH R21 "Improved CRISPR gene drive systems with reduced resistance allele formation"
Congratulations to Joan Chung and Chen Liu for presenting a talk at the Cornell undergraduate research symposium! "Applications and development of homing gene drives"

July 2017
Paper published in PLOS Genetics: "Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations"
Talk at the Cold Spring Harbor CRISPR Conference. "CRISPR gene drives with reduced resistance allele formation"
Public Outreach: "Ask Me Anything" on Reddit
Press:
Gene Drives Will Need a Tune-Up to Power Past Resistance
Gene drives likely to be foiled by rapid rise of resistance
Resistance to CRISPR gene drives may arise easily
Genetically Engineering Nature Will Be Way More Complicated Than We Thought
The gene drive bubble: New realities

June 2017
New paper on bioRxiv: "Reducing resistance allele formation in CRISPR gene drives" (updated version published in May 2018)

April 2017
Poster presentation at the Genetics Society of America Drosophila Research Conference. "Resistance allele formation and genetic diversity in Drosophila CRISPR/Cas9 gene drives"

February 2017
New paper on bioRxiv: "Novel CRISPR/Cas9 gene drive constructs in Drosophila reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations" (updated version published in July 2017)

May 2016
Jackson Champer joins the Messer and Clark labs at Cornell University as a postdoc